Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

In Parkinson's disease (PD), there is a progressive loss of neuromelanin (NM)-containing dopamine (DA) neurons in substantia nigra (SN) which is associated with microgliosis and presence of extracellular NM. Herein, we have investigated the interplay between microglia and human NM on the degene...

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Hauptverfasser: Zhang, Wei, Phillips, Kester, Wielgus, Albert R., Liu, Jie, Albertini, Alberto, Zucca, Fabio A., Faust, Rudolph, Qian, Steven Y., Miller, David S., Chignell, Colin F., Wilson, Belinda, Jackson-Lewis, Vernice, Przedborski, Serge, Joset, Danielle, Loike, John, Hong, Jau-Shyong, Sulzer, David, Zecca, Luigi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603276/
https://ncbi.nlm.nih.gov/pubmed/19957214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-009-9140-z
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