Reactive microgliosis: extracellular μ-calpain and microglia-mediated dopaminergic neurotoxicity

Microglia, the innate immune cells in the brain, can become chronically activated in response to dopaminergic neuron death, fuelling a self-renewing cycle of microglial activation followed by further neuron damage (reactive microgliosis), which is implicated in the progressive nature of Parkinson’s...

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Detalhes bibliográficos
Main Authors: Levesque, Shannon, Wilson, Belinda, Gregoria, Vincent, Thorpe, Laura B., Dallas, Shannon, Polikov, Vadim S., Hong, Jau-Shyong, Block, Michelle L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860703/
https://ncbi.nlm.nih.gov/pubmed/20123724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awp333
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