Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

In Parkinson's disease (PD), there is a progressive loss of neuromelanin (NM)-containing dopamine (DA) neurons in substantia nigra (SN) which is associated with microgliosis and presence of extracellular NM. Herein, we have investigated the interplay between microglia and human NM on the degene...

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Main Authors: Zhang, Wei, Phillips, Kester, Wielgus, Albert R., Liu, Jie, Albertini, Alberto, Zucca, Fabio A., Faust, Rudolph, Qian, Steven Y., Miller, David S., Chignell, Colin F., Wilson, Belinda, Jackson-Lewis, Vernice, Przedborski, Serge, Joset, Danielle, Loike, John, Hong, Jau-Shyong, Sulzer, David, Zecca, Luigi
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603276/
https://ncbi.nlm.nih.gov/pubmed/19957214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-009-9140-z
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