Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

BACKGROUND: The neuropathology of Parkinson's disease (PD) includes loss of dopaminergic neurons in the substantia nigra, nitrated α-synuclein (N-α-Syn) enriched intraneuronal inclusions or Lewy bodies and neuroinflammation. While the contribution of innate microglial inflammatory activities to...

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Bibliografiska uppgifter
Huvudupphovsmän: Benner, Eric J., Banerjee, Rebecca, Reynolds, Ashley D., Sherman, Simon, Pisarev, Vladimir M., Tsiperson, Vladislav, Nemachek, Craig, Ciborowski, Pawel, Przedborski, Serge, Mosley, R. Lee, Gendelman, Howard E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2008
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2147051/
https://ncbi.nlm.nih.gov/pubmed/18167537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001376
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