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RTP801 Is Elevated in Parkinson Brain Substantia Nigral Neurons and Mediates Death in Cellular Models of Parkinson's Disease by a Mechanism Involving Mammalian Target of Rapamycin Inactivation

The molecules underlying neuron loss in Parkinson's disease (PD) are essentially unknown, and current therapies focus on diminishing symptoms rather than preventing neuron death. We identified RTP801 as a gene whose transcripts were highly induced in a cellular model of PD in which death of neu...

詳細記述

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書誌詳細
出版年:J Neurosci
主要な著者: Malagelada, Cristina, Ryu, Elizabeth J., Biswas, Subhas C., Jackson-Lewis, Vernice, Greene, Lloyd A.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674487/
https://ncbi.nlm.nih.gov/pubmed/17005863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3292-06.2006
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