Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors

Smad1 is a downstream effector of the BMP signaling pathway that binds regulatory DNA to execute gene expression programs leading to, for example, the maintenance of pluripotency in mice. On the contrary, the TGF-β-activated Smad3 triggers strikingly different programs such as mesodermal differentia...

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Bibliografiska uppgifter
Huvudupphovsmän: BabuRajendran, Nithya, Palasingam, Paaventhan, Narasimhan, Kamesh, Sun, Wenjie, Prabhakar, Shyam, Jauch, Ralf, Kolatkar, Prasanna R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
Ämnen:
Structural Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879523/
https://ncbi.nlm.nih.gov/pubmed/20147459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq046
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