Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers

Smad proteins form multimeric complexes consisting of the ‘common partner’ Smad4 and receptor regulated R-Smads on clustered DNA binding sites. Deciphering how pathway specific Smad complexes multimerize on DNA to regulate gene expression is critical for a better understanding of the cis-regulatory...

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Detalles Bibliográficos
Main Authors: Baburajendran, Nithya, Jauch, Ralf, Tan, Clara Yueh Zhen, Narasimhan, Kamesh, Kolatkar, Prasanna R.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185416/
https://ncbi.nlm.nih.gov/pubmed/21724602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr500
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