Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors

Smad1 is a downstream effector of the BMP signaling pathway that binds regulatory DNA to execute gene expression programs leading to, for example, the maintenance of pluripotency in mice. On the contrary, the TGF-β-activated Smad3 triggers strikingly different programs such as mesodermal differentia...

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Main Authors: BabuRajendran, Nithya, Palasingam, Paaventhan, Narasimhan, Kamesh, Sun, Wenjie, Prabhakar, Shyam, Jauch, Ralf, Kolatkar, Prasanna R.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2010
主題:
Structural Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879523/
https://ncbi.nlm.nih.gov/pubmed/20147459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq046
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