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Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

Gene silencing by double-stranded RNA, denoted RNA interference, represents a new paradigm for rational drug design1. However, the transformative therapeutic potential of short interfering RNA (siRNA) has been stymied by a key obstacle—safe delivery to specified target cells in vivo2. Macrophages ar...

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Autors principals: Aouadi, Myriam, Tesz, Gregory J., Nicoloro, Sarah M., Wang, Mengxi, Chouinard, My, Soto, Ernesto, Ostroff, Gary R., Czech, Michael P.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879154/
https://ncbi.nlm.nih.gov/pubmed/19407801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07774
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