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Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
Gene silencing by double-stranded RNA, denoted RNA interference, represents a new paradigm for rational drug design1. However, the transformative therapeutic potential of short interfering RNA (siRNA) has been stymied by a key obstacle—safe delivery to specified target cells in vivo2. Macrophages ar...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2879154/ https://ncbi.nlm.nih.gov/pubmed/19407801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07774 |
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