CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

Intracellular therapeutic targets that define tumor immunosuppression in both tumor cells and T cells remain intractable. Here, we have shown that administration of a covalently linked siRNA to an aptamer (apt) that selectively binds cytotoxic T lymphocyte–associated antigen 4 (CTLA4(apt)) allows ge...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Herrmann, Andreas, Priceman, Saul J., Kujawski, Maciej, Xin, Hong, Cherryholmes, Gregory A., Zhang, Wang, Zhang, Chunyan, Lahtz, Christoph, Kowolik, Claudia, Forman, Steve J., Kortylewski, Marcin, Yu, Hua
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2014
Gaiak:
Technical Advance
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071407/
https://ncbi.nlm.nih.gov/pubmed/24892807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73174
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