CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

Intracellular therapeutic targets that define tumor immunosuppression in both tumor cells and T cells remain intractable. Here, we have shown that administration of a covalently linked siRNA to an aptamer (apt) that selectively binds cytotoxic T lymphocyte–associated antigen 4 (CTLA4(apt)) allows ge...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Herrmann, Andreas, Priceman, Saul J., Kujawski, Maciej, Xin, Hong, Cherryholmes, Gregory A., Zhang, Wang, Zhang, Chunyan, Lahtz, Christoph, Kowolik, Claudia, Forman, Steve J., Kortylewski, Marcin, Yu, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071407/
https://ncbi.nlm.nih.gov/pubmed/24892807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73174
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados