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CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells
Intracellular therapeutic targets that define tumor immunosuppression in both tumor cells and T cells remain intractable. Here, we have shown that administration of a covalently linked siRNA to an aptamer (apt) that selectively binds cytotoxic T lymphocyte–associated antigen 4 (CTLA4(apt)) allows ge...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4071407/ https://ncbi.nlm.nih.gov/pubmed/24892807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73174 |
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