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Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA

Translation of siRNA technology into the clinic is limited by the need for improved delivery systems that target specific cell types. Macrophages are particularly attractive targets for RNAi therapy because they promote pathogenic inflammatory responses in a number of important human diseases. We pr...

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發表在:Mol Pharm
Main Authors: Cohen, Jessica L., Shen, Yuefei, Aouadi, Myriam, Vangala, Pranitha, Tencerova, Michaela, Amano, Shinya U., Nicoloro, Sarah M., Yawe, Joseph C., Czech, Michael P.
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153885/
https://ncbi.nlm.nih.gov/pubmed/26815386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00831
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