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Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA

Translation of siRNA technology into the clinic is limited by the need for improved delivery systems that target specific cell types. Macrophages are particularly attractive targets for RNAi therapy because they promote pathogenic inflammatory responses in a number of important human diseases. We pr...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Pharm
Hauptverfasser: Cohen, Jessica L., Shen, Yuefei, Aouadi, Myriam, Vangala, Pranitha, Tencerova, Michaela, Amano, Shinya U., Nicoloro, Sarah M., Yawe, Joseph C., Czech, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153885/
https://ncbi.nlm.nih.gov/pubmed/26815386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00831
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