Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice

Adipose tissue (AT) inflammation and infiltration by macrophages is associated with insulin resistance and type 2 diabetes in obese humans, offering a potential target for therapeutics. However, whether AT macrophages (ATMs) directly contribute to systemic glucose intolerance has not been determined...

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Main Authors: Aouadi, Myriam, Tencerova, Michaela, Vangala, Pranitha, Yawe, Joseph C., Nicoloro, Sarah M., Amano, Shinya U., Cohen, Jessica L., Czech, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657808/
https://ncbi.nlm.nih.gov/pubmed/23630254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300492110
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