The Mitochondrial 2-Oxoglutarate Carrier Is Part of a Metabolic Pathway That Mediates Glucose- and Glutamine-stimulated Insulin Secretion

Glucose-stimulated insulin secretion from pancreatic islet β-cells is dependent in part on pyruvate cycling through the pyruvate/isocitrate pathway, which generates cytosolic α-ketoglutarate, also known as 2-oxoglutarate (2OG). Here, we have investigated if mitochondrial transport of 2OG through the...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Odegaard, Matthew L., Joseph, Jamie W., Jensen, Mette V., Lu, Danhong, Ilkayeva, Olga, Ronnebaum, Sarah M., Becker, Thomas C., Newgard, Christopher B.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2010
Θέματα:
Metabolism
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878081/
https://ncbi.nlm.nih.gov/pubmed/20356834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092593
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια