Silencing of Cytosolic or Mitochondrial Isoforms of Malic Enzyme Has No Effect on Glucose-stimulated Insulin Secretion from Rodent Islets

We have previously demonstrated a role for pyruvate cycling in glucose-stimulated insulin secretion (GSIS). Some of the possible pyruvate cycling pathways are completed by conversion of malate to pyruvate by malic enzyme. Using INS-1-derived 832/13 cells, it has recently been shown by other laborato...

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Bibliographische Detailangaben
Hauptverfasser: Ronnebaum, Sarah M., Jensen, Mette V., Hohmeier, Hans E., Burgess, Shawn C., Zhou, Yun-Ping, Qian, Su, MacNeil, Douglas, Howard, Andrew, Thornberry, Nancy, Ilkayeva, Olga, Lu, Danhong, Sherry, A. Dean, Newgard, Christopher B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Metabolism and Bioenergetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570884/
https://ncbi.nlm.nih.gov/pubmed/18755687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804665200
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