Chronic Suppression of Acetyl-CoA Carboxylase 1 in β-Cells Impairs Insulin Secretion via Inhibition of Glucose Rather Than Lipid Metabolism

Acetyl-CoA carboxylase 1 (ACC1) currently is being investigated as a target for treatment of obesity-associated dyslipidemia and insulin resistance. To investigate the effects of ACC1 inhibition on insulin secretion, three small interfering RNA (siRNA) duplexes targeting ACC1 (siACC1) were transfect...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Ronnebaum, Sarah M., Joseph, Jamie W., Ilkayeva, Olga, Burgess, Shawn C., Lu, Danhong, Becker, Thomas C., Sherry, A. Dean, Newgard, Christopher B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Metabolism and Bioenergetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386941/
https://ncbi.nlm.nih.gov/pubmed/18381287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800119200
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars