Chronic Suppression of Acetyl-CoA Carboxylase 1 in β-Cells Impairs Insulin Secretion via Inhibition of Glucose Rather Than Lipid Metabolism

Acetyl-CoA carboxylase 1 (ACC1) currently is being investigated as a target for treatment of obesity-associated dyslipidemia and insulin resistance. To investigate the effects of ACC1 inhibition on insulin secretion, three small interfering RNA (siRNA) duplexes targeting ACC1 (siACC1) were transfect...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Ronnebaum, Sarah M., Joseph, Jamie W., Ilkayeva, Olga, Burgess, Shawn C., Lu, Danhong, Becker, Thomas C., Sherry, A. Dean, Newgard, Christopher B.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2008
الموضوعات:
Metabolism and Bioenergetics
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386941/
https://ncbi.nlm.nih.gov/pubmed/18381287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800119200
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