Chronic Suppression of Acetyl-CoA Carboxylase 1 in β-Cells Impairs Insulin Secretion via Inhibition of Glucose Rather Than Lipid Metabolism

Acetyl-CoA carboxylase 1 (ACC1) currently is being investigated as a target for treatment of obesity-associated dyslipidemia and insulin resistance. To investigate the effects of ACC1 inhibition on insulin secretion, three small interfering RNA (siRNA) duplexes targeting ACC1 (siACC1) were transfect...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ronnebaum, Sarah M., Joseph, Jamie W., Ilkayeva, Olga, Burgess, Shawn C., Lu, Danhong, Becker, Thomas C., Sherry, A. Dean, Newgard, Christopher B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386941/
https://ncbi.nlm.nih.gov/pubmed/18381287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800119200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados