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Interaction between DNA Polymerase λ and Anticancer Nucleoside Analogs
The anticancer activity of cytarabine (AraC) and gemcitabine (dFdC) is thought to result from chain termination after incorporation into DNA. To investigate their incorporation into DNA at atomic level resolution, we present crystal structures of human DNA polymerase λ (Pol λ) bound to gapped DNA an...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2878035/ https://ncbi.nlm.nih.gov/pubmed/20348107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094391 |
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