Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Nucleotide biosynthesis pathways have been reported to be essential in some protozoan pathogens. Hence, we evaluated the essentiality of one enzyme in the pyrimidine biosyn-thetic pathway, dihydroorotate dehydrogenase (DHODH) from the eukaryotic parasite Trypanosoma brucei through gene knockdown stu...

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Main Authors: Arakaki, Tracy L, Buckner, Frederick S, Gillespie, J Robert, Malmquist, Nicholas A, Phillips, Margaret A, Kalyuzhniy, Oleksandr, Luft, Joseph R, DeTitta, George T, Verlinde, Christophe L M J, Van Voorhis, Wesley C, Hol, Wim G J, Merritt, Ethan A
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877593/
https://ncbi.nlm.nih.gov/pubmed/18312275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2008.06131.x
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