Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice

Human African trypanosomiasis continues to be an important public health threat in extensive regions of sub-Saharan Africa. Treatment options for infected patients are unsatisfactory due to toxicity, difficult administration regimes, and poor efficacy of available drugs. The aminoacyl-tRNA synthetas...

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Autori principali: Shibata, Sayaka, Gillespie, J. Robert, Kelley, Angela M., Napuli, Alberto J., Zhang, Zhongsheng, Kovzun, Kuzma V., Pefley, Ranae M., Lam, Jocelyn, Zucker, Frank H., Van Voorhis, Wesley C., Merritt, Ethan A., Hol, Wim G. J., Verlinde, Christophe L. M. J., Fan, Erkang, Buckner, Frederick S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088252/
https://ncbi.nlm.nih.gov/pubmed/21282428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01796-10
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