PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells

Overexpression of epidermal growth factor receptor (EGFR) is found in over 80% of head and neck squamous cell carcinomas (HNSCC) and associated with poor clinical outcomes. EFGR selective tyrosine kinase inhibitors (TKIs) or antibodies have recently emerged as promising treatments for solid tumors,...

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Detalhes bibliográficos
Main Authors: Sun, Q, Ming, L, Thomas, SM, Wang, Y, Chen, ZG, Ferris, RL, Grandis, JR, Zhang, L, Yu, J
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872091/
https://ncbi.nlm.nih.gov/pubmed/19421143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.108
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