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Trp-26 Imparts Functional Versatility to Human α-Defensin HNP1
We performed a comprehensive alanine scan of human α-defensin HNP1 and tested the ability of the resulting analogs to kill Staphylococcus aureus, inhibit anthrax lethal factor, and bind human immunodeficiency virus-1 gp120. By far, the most deleterious mutation for all of these functions was W26A. T...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871495/ https://ncbi.nlm.nih.gov/pubmed/20220136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102749 |
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