Sometimes It Takes Two to Tango: CONTRIBUTIONS OF DIMERIZATION TO FUNCTIONS OF HUMAN α-DEFENSIN HNP1 PEPTIDE

Human myeloid α-defensins called HNPs play multiple roles in innate host defense. The Trp-26 residue of HNP1 was previously shown to contribute importantly to its ability to kill S. aureus, inhibit anthrax lethal factor (LF), bind gp120 of HIV-1, dimerize, and undergo further self-association. To ga...

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Detalhes bibliográficos
Main Authors: Pazgier, Marzena, Wei, Gang, Ericksen, Bryan, Jung, Grace, Wu, Zhibin, de Leeuw, Erik, Yuan, Weirong, Szmacinski, Henryk, Lu, Wei-Yue, Lubkowski, Jacek, Lehrer, Robert I., Lu, Wuyuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308808/
https://ncbi.nlm.nih.gov/pubmed/22270360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.332205
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