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Invariant Gly Residue Is Important for α-Defensin Folding, Dimerization, and Function: A CASE STUDY OF THE HUMAN NEUTROPHIL α-DEFENSIN HNP1

The human α-defensins (HNP) are synthesized in vivo as inactive prodefensins, and contain a conserved glycine, Gly(17), which is part of a β-bulge structure. It had previously been shown that the glycine main chain torsion angles are in a d-configuration, and that d-amino acids but not l-alanine cou...

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Detalhes bibliográficos
Main Authors: Zhao, Le, Ericksen, Bryan, Wu, Xueji, Zhan, Changyou, Yuan, Weirong, Li, Xu, Pazgier, Marzena, Lu, Wuyuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365925/
https://ncbi.nlm.nih.gov/pubmed/22496447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.355255
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