Trp-26 Imparts Functional Versatility to Human α-Defensin HNP1

We performed a comprehensive alanine scan of human α-defensin HNP1 and tested the ability of the resulting analogs to kill Staphylococcus aureus, inhibit anthrax lethal factor, and bind human immunodeficiency virus-1 gp120. By far, the most deleterious mutation for all of these functions was W26A. T...

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Bibliografiske detaljer
Main Authors: Wei, Gang, Pazgier, Marzena, de Leeuw, Erik, Rajabi, Mohsen, Li, Jing, Zou, Guozhang, Jung, Grace, Yuan, Weirong, Lu, Wei-Yue, Lehrer, Robert I., Lu, Wuyuan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871495/
https://ncbi.nlm.nih.gov/pubmed/20220136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102749
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