The Conserved Salt Bridge in Human α-Defensin 5 Is Required for Its Precursor Processing and Proteolytic Stability

Mammalian α-defensins, expressed primarily in leukocytes and epithelia, play important roles in innate and adaptive immune responses to microbial infection. Six invariant cysteine residues forming three indispensable disulfide bonds and one Gly residue required structurally for an atypical β-bulge a...

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Библиографические подробности
Главные авторы: Rajabi, Mohsen, de Leeuw, Erik, Pazgier, Marzena, Li, Jing, Lubkowski, Jacek, Lu, Wuyuan
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2008
Предметы:
Protein Synthesis, Post-Translational Modification, and Degradation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490794/
https://ncbi.nlm.nih.gov/pubmed/18499668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801851200
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