The Conserved Salt Bridge in Human α-Defensin 5 Is Required for Its Precursor Processing and Proteolytic Stability

Mammalian α-defensins, expressed primarily in leukocytes and epithelia, play important roles in innate and adaptive immune responses to microbial infection. Six invariant cysteine residues forming three indispensable disulfide bonds and one Gly residue required structurally for an atypical β-bulge a...

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Detalhes bibliográficos
Main Authors: Rajabi, Mohsen, de Leeuw, Erik, Pazgier, Marzena, Li, Jing, Lubkowski, Jacek, Lu, Wuyuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490794/
https://ncbi.nlm.nih.gov/pubmed/18499668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801851200
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