The Conserved Salt Bridge in Human α-Defensin 5 Is Required for Its Precursor Processing and Proteolytic Stability

Mammalian α-defensins, expressed primarily in leukocytes and epithelia, play important roles in innate and adaptive immune responses to microbial infection. Six invariant cysteine residues forming three indispensable disulfide bonds and one Gly residue required structurally for an atypical β-bulge a...

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Autores principales: Rajabi, Mohsen, de Leeuw, Erik, Pazgier, Marzena, Li, Jing, Lubkowski, Jacek, Lu, Wuyuan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490794/
https://ncbi.nlm.nih.gov/pubmed/18499668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801851200
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