SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Huntington’s disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal transcription and metabolism. Here, we demonstrate that inhibition of sirtuin 2 (SIRT2) achieves neuroprotection in cellular and invertebrate...

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Bibliografische gegevens
Hoofdauteurs: Luthi-Carter, Ruth, Taylor, David M., Pallos, Judit, Lambert, Emmanuel, Amore, Allison, Parker, Alex, Moffitt, Hilary, Smith, Donna L., Runne, Heike, Gokce, Ozgun, Kuhn, Alexandre, Xiang, Zhongmin, Maxwell, Michele M., Reeves, Steven A., Bates, Gillian P., Neri, Christian, Thompson, Leslie M., Marsh, J. Lawrence, Kazantsev, Aleksey G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2010
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867924/
https://ncbi.nlm.nih.gov/pubmed/20378838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002924107
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