Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry

Gene expression changes are a hallmark of the neuropathology of Huntington's disease (HD), but the exact molecular mechanisms of this effect remain uncertain. Here, we report that in vitro models of disease comprised of primary striatal neurons expressing N-terminal fragments of mutant huntingt...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Runne, Heike, Régulier, Etienne, Kuhn, Alexandre, Zala, Diana, Gokce, Ozgun, Perrin, Valérie, Sick, Beate, Aebischer, Patrick, Déglon, Nicole, Luthi-Carter, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671220/
https://ncbi.nlm.nih.gov/pubmed/18815258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3044-08.2008
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