A carregar...

Inhibition of Calcineurin by FK506 Protects against Polyglutamine-Huntingtin Toxicity through an Increase of Huntingtin Phosphorylation at S421

Huntington’s disease (HD) is caused by an abnormal expanded polyglutamine (polyQ) repeat in the huntingtin protein. Insulin-like growth factor-1 acting through the prosurvival kinase Akt mediates the phosphorylation of huntingtin at S421 and inhibits the toxicity of polyQ-expanded huntingtin in cell...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Pardo, Raúl, Colin, Emilie, Régulier, Etienne, Aebischer, Patrick, Déglon, Nicole, Humbert, Sandrine, Saudou, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675484/
https://ncbi.nlm.nih.gov/pubmed/16452687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3706-05.2006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!