Inhibition of Calcineurin by FK506 Protects against Polyglutamine-Huntingtin Toxicity through an Increase of Huntingtin Phosphorylation at S421

Huntington’s disease (HD) is caused by an abnormal expanded polyglutamine (polyQ) repeat in the huntingtin protein. Insulin-like growth factor-1 acting through the prosurvival kinase Akt mediates the phosphorylation of huntingtin at S421 and inhibits the toxicity of polyQ-expanded huntingtin in cell...

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Publicado en:J Neurosci
Autores principales: Pardo, Raúl, Colin, Emilie, Régulier, Etienne, Aebischer, Patrick, Déglon, Nicole, Humbert, Sandrine, Saudou, Frédéric
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675484/
https://ncbi.nlm.nih.gov/pubmed/16452687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3706-05.2006
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