Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry

Gene expression changes are a hallmark of the neuropathology of Huntington's disease (HD), but the exact molecular mechanisms of this effect remain uncertain. Here, we report that in vitro models of disease comprised of primary striatal neurons expressing N-terminal fragments of mutant huntingt...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Runne, Heike, Régulier, Etienne, Kuhn, Alexandre, Zala, Diana, Gokce, Ozgun, Perrin, Valérie, Sick, Beate, Aebischer, Patrick, Déglon, Nicole, Luthi-Carter, Ruth
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2008
Assuntos:
Brief Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671220/
https://ncbi.nlm.nih.gov/pubmed/18815258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3044-08.2008
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares