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Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation

BACKGROUND: The molecular phenotype of Huntington's disease (HD) is known to comprise highly reproducible changes in gene expression involving striatal signaling genes. Here we test whether individual changes in striatal gene expression are capable of mitigating HD-related neurotoxicity. METHOD...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Seredenina, Tamara, Gokce, Ozgun, Luthi-Carter, Ruth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136499/
https://ncbi.nlm.nih.gov/pubmed/21779398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022231
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