SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Huntington’s disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal transcription and metabolism. Here, we demonstrate that inhibition of sirtuin 2 (SIRT2) achieves neuroprotection in cellular and invertebrate...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Luthi-Carter, Ruth, Taylor, David M., Pallos, Judit, Lambert, Emmanuel, Amore, Allison, Parker, Alex, Moffitt, Hilary, Smith, Donna L., Runne, Heike, Gokce, Ozgun, Kuhn, Alexandre, Xiang, Zhongmin, Maxwell, Michele M., Reeves, Steven A., Bates, Gillian P., Neri, Christian, Thompson, Leslie M., Marsh, J. Lawrence, Kazantsev, Aleksey G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867924/
https://ncbi.nlm.nih.gov/pubmed/20378838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002924107
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