SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Huntington’s disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal transcription and metabolism. Here, we demonstrate that inhibition of sirtuin 2 (SIRT2) achieves neuroprotection in cellular and invertebrate...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Luthi-Carter, Ruth, Taylor, David M., Pallos, Judit, Lambert, Emmanuel, Amore, Allison, Parker, Alex, Moffitt, Hilary, Smith, Donna L., Runne, Heike, Gokce, Ozgun, Kuhn, Alexandre, Xiang, Zhongmin, Maxwell, Michele M., Reeves, Steven A., Bates, Gillian P., Neri, Christian, Thompson, Leslie M., Marsh, J. Lawrence, Kazantsev, Aleksey G.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2010
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867924/
https://ncbi.nlm.nih.gov/pubmed/20378838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002924107
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια