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Salmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells

A fundamental challenge in gene therapy is to develop approaches for delivering nucleic acid-based gene interfering agents, such as small interfering RNAs and ribozymes, to the appropriate cells in a way that is tissue/cell specific, efficient, and safe. Using human cytomegalovirus (HCMV) infection...

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Autores principales: Bai, Yong, Li, Hongjian, Vu, Gia-Phong, Gong, Hao, Umamoto, Sean, Zhou, Tianhong, Lu, Sangwei, Liu, Fenyong
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867731/
https://ncbi.nlm.nih.gov/pubmed/20360564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912813107
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