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Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice

Safe, effective, and tissue-specific delivery is a central issue for the therapeutic application of nucleic-acid-based gene interfering agents, such as ribozymes and siRNAs. In this study, we constructed a functional RNase P-based ribozyme (M1GS RNA) that targets the overlapping mRNA region of M80.5...

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Bibliografiske detaljer
Main Authors: Bai, Yong, Gong, Hao, Li, Hongjian, Vu, Gia-Phong, Lu, Sangwei, Liu, Fenyong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044408/
https://ncbi.nlm.nih.gov/pubmed/21300908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014975108
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