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Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice
Safe, effective, and tissue-specific delivery is a central issue for the therapeutic application of nucleic-acid-based gene interfering agents, such as ribozymes and siRNAs. In this study, we constructed a functional RNase P-based ribozyme (M1GS RNA) that targets the overlapping mRNA region of M80.5...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044408/ https://ncbi.nlm.nih.gov/pubmed/21300908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014975108 |
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