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Effective Inhibition of Human Immunodeficiency Virus 1 Replication by Engineered RNase P Ribozyme

Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study, a variant was used to target the HIV RNA sequence in the tat region. The variant cleaved the tat RNA sequence in vitro about 20 times more ef...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Zeng, Wenbo, Chen, Yuan-Chuan, Bai, Yong, Trang, Phong, Vu, Gia-Phong, Lu, Sangwei, Wu, Jianguo, Liu, Fenyong
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2012
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530568/
https://ncbi.nlm.nih.gov/pubmed/23300569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051855
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