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Effective Inhibition of Human Immunodeficiency Virus 1 Replication by Engineered RNase P Ribozyme
Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study, a variant was used to target the HIV RNA sequence in the tat region. The variant cleaved the tat RNA sequence in vitro about 20 times more ef...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3530568/ https://ncbi.nlm.nih.gov/pubmed/23300569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051855 |
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