RNase P-Associated External Guide Sequence Effectively Reduces the Expression of Human CC-Chemokine Receptor 5 and Inhibits the Infection of Human Immunodeficiency Virus 1

External guide sequences (EGSs) represent a new class of RNA-based gene-targeting agents, consist of a sequence complementary to a target mRNA, and render the target RNA susceptible to degradation by ribonuclease P (RNase P). In this study, EGSs were constructed to target the mRNA encoding human CC-...

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Autors principals: Zeng, Wenbo, Vu, Gia-Phong, Bai, Yong, Chen, Yuan-Chuan, Trang, Phong, Lu, Sangwei, Xiao, Gengfu, Liu, Fenyong
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591226/
https://ncbi.nlm.nih.gov/pubmed/23509733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/509714
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