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Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA

A functional RNase P ribozyme (M1GS RNA) was constructed to target the overlapping mRNA region of two murine cytomegalovirus (MCMV) capsid proteins essential for viral replication: the assembly protein (mAP) and M80. The customized ribozyme efficiently cleaved the target mRNA sequence in vitro. More...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bai, Yong, Trang, Phong, Li, Hongjian, Kim, Kihoon, Zhou, Tianhong, Liu, Fenyong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504777/
https://ncbi.nlm.nih.gov/pubmed/18663226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804922105
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