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Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA
A functional RNase P ribozyme (M1GS RNA) was constructed to target the overlapping mRNA region of two murine cytomegalovirus (MCMV) capsid proteins essential for viral replication: the assembly protein (mAP) and M80. The customized ribozyme efficiently cleaved the target mRNA sequence in vitro. More...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2504777/ https://ncbi.nlm.nih.gov/pubmed/18663226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804922105 |
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