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Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA

A functional RNase P ribozyme (M1GS RNA) was constructed to target the overlapping mRNA region of two murine cytomegalovirus (MCMV) capsid proteins essential for viral replication: the assembly protein (mAP) and M80. The customized ribozyme efficiently cleaved the target mRNA sequence in vitro. More...

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Detalhes bibliográficos
Main Authors: Bai, Yong, Trang, Phong, Li, Hongjian, Kim, Kihoon, Zhou, Tianhong, Liu, Fenyong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504777/
https://ncbi.nlm.nih.gov/pubmed/18663226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804922105
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