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RNase P ribozyme inhibits cytomegalovirus replication by blocking the expression of viral capsid proteins

By linking a guide sequence to the catalytic RNA subunit of RNase P (M1 RNA), we constructed a functional ribozyme (M1GS RNA) that targets the overlapping mRNA region of two human cytomegalovirus (HCMV) capsid proteins, the capsid scaffolding protein (CSP) and assemblin, which are essential for vira...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Kim, Kihoon, Trang, Phong, Umamoto, Sean, Hai, Rong, Liu, Fenyong
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443536/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15220469/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh660
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