RNase P Ribozymes Inhibit the Replication of Human Cytomegalovirus by Targeting Essential Viral Capsid Proteins

An engineered RNase P-based ribozyme variant, which was generated using the in vitro selection procedure, was used to target the overlapping mRNA region of two proteins essential for human cytomegalovirus (HCMV) replication: capsid assembly protein (AP) and protease (PR). In vitro studies showed tha...

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Bibliographic Details
Published in:Viruses
Main Authors: Yang, Zhu, Reeves, Michael, Ye, Jun, Trang, Phong, Zhu, Li, Sheng, Jingxue, Wang, Yu, Zen, Ke, Wu, Jianguo, Liu, Fenyong
Format: Artigo
Language:Inglês
Published: MDPI 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517104/
https://ncbi.nlm.nih.gov/pubmed/26114473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v7072775
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