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Intracellular expression of engineered RNase P ribozymes effectively blocks gene expression and replication of human cytomegalovirus
A ribozyme (M1GS RNA) constructed from the catalytic RNA subunit of RNase P from Escherichia coli was used to target the overlapping region of two human cytomegalovirus (HCMV) mRNAs, which encode for the viral essential protease (PR) and capsid assembly proteins (AP), respectively. The results show...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Copyright 2004 by RNA Society
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370939/ https://ncbi.nlm.nih.gov/pubmed/14970389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5178404 |
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