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Intracellular expression of engineered RNase P ribozymes effectively blocks gene expression and replication of human cytomegalovirus

A ribozyme (M1GS RNA) constructed from the catalytic RNA subunit of RNase P from Escherichia coli was used to target the overlapping region of two human cytomegalovirus (HCMV) mRNAs, which encode for the viral essential protease (PR) and capsid assembly proteins (AP), respectively. The results show...

詳細記述

保存先:
書誌詳細
主要な著者: KIM, KIHOON, UMAMOTO, SEAN, TRANG, PHONG, HAI, RONG, LIU, FENYONG
フォーマット: Artigo
言語:Inglês
出版事項: Copyright 2004 by RNA Society 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370939/
https://ncbi.nlm.nih.gov/pubmed/14970389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5178404
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