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Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1

Abundant structural information exists on how thrombin recognizes ligands at the active site or at exosites separate from the active site region, but remarkably little is known about how thrombin recognizes substrates that bridge both the active site and exosite I. The case of the protease-activated...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gandhi, Prafull S., Chen, Zhiwei, Di Cera, Enrico
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865304/
https://ncbi.nlm.nih.gov/pubmed/20236938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.115337
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