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Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1

Abundant structural information exists on how thrombin recognizes ligands at the active site or at exosites separate from the active site region, but remarkably little is known about how thrombin recognizes substrates that bridge both the active site and exosite I. The case of the protease-activated...

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מידע ביבליוגרפי
Main Authors: Gandhi, Prafull S., Chen, Zhiwei, Di Cera, Enrico
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865304/
https://ncbi.nlm.nih.gov/pubmed/20236938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.115337
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