Esperamicins, a class of potent antitumor antibiotics: mechanism of action.

The esperamicins represent a class of antitumor antibiotics characterized by an unusual chemical core structure and extremely potent cytotoxicity. The mechanism by which these drugs produce cytotoxicity was investigated and found to be related to the formation of single- and double-strand DNA breaks...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Long, B H, Golik, J, Forenza, S, Ward, B, Rehfuss, R, Dabrowiak, J C, Catino, J J, Musial, S T, Brookshire, K W, Doyle, T W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286391/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2643098/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.1.2
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