DNA intercalation and cleavage of an antitumor antibiotic dynemicin that contains anthracycline and enediyne cores.
Dynemicin is a hybrid containing anthraquinone and enediyne cores, which contribute to binding and cleavage of DNA, respectively. DNA strand scission by the antitumor antibiotic is significantly enhanced by the addition of NADPH or thiol compounds. The preferential cutting site of dynemicin is on th...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53997/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2339123/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.10.3831 |
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